In the AS-TRANSFER project (funded by URBACT), four cities exchange knowledge about how to develop their Industry 4.0 ecosystems. Manufacturing industries are still the beating heart of many European industrial city regions. But global competition is tough, and traditional business practices are under fire, challenged by digitalization. How can cities best deal with the challenges of the quite disruptive “Industry 4.0” era? We support this network in finding out, and developing local action plans.